COG112, ApoE Mimetic Peptide
Price range: $166.30 through $728.00
COG112 is a synthetic Apolipoprotein E (ApoE) mimetic peptide designed by conjugating the receptor-binding domain of ApoE (COG133) with the cell-penetrating peptide (CPP) antennapedia (Antp). This modification significantly enhances the peptide’s anti-inflammatory properties and neuroprotective effects compared to COG133 alone.
COG112 ApoE Mimetic Peptide | Anti-Inflammatory & Neuroprotective Research Peptide
Product Overview:
COG112 is a synthetic Apolipoprotein E (ApoE) mimetic peptide designed by conjugating the receptor-binding domain of ApoE (COG133) with the cell-penetrating peptide (CPP) antennapedia (Antp). This modification significantly enhances the peptide’s anti-inflammatory properties and neuroprotective effects compared to COG133 alone.
Sequence:
acetyl-YRQIKIWFQNRRMKWKKCLRVRLASHLRKLRKRLL-amide
Molecular Formula:
C202H347N71O38S2
Molecular Weight:
4460.51 g/mol
Key Features and Uses:
● ApoE mimetic peptide COG112 is extensively studied for its ability to modulate inflammatory responses, primarily by inhibiting the NF-κB signaling pathway.
● Exhibits potent anti-inflammatory properties useful for research into neurodegenerative diseases and inflammatory bowel disease.
● Compared to the original ApoE peptide COG133, COG112 demonstrates enhanced cell penetration and therapeutic efficacy due to the CPP antennapedia conjugation.
● Recent research highlights the role of COG112 in cancer biology by inhibiting the SET-Rac1 interaction, resulting in decreased cancer cell migration and invasion.
● COG112 peptide is widely used in anti-inflammatory uses and ApoE peptide research studies to explore novel therapeutic applications.
Research Insights:
● COG112 vs COG133 ApoE peptide: The addition of the CPP domain in COG112 dramatically improves cellular uptake and anti-inflammatory activity compared to COG133 alone, making it a superior candidate for experimental therapies targeting inflammation and neuroprotection.
●Potential applications include modulation of inflammatory bowel disease, neurodegenerative disorders such as Alzheimer’s disease, and oncology research focused on tumor invasion and metastasis.
Product Applications:
Ideal for scientists and researchers investigating:
● Inflammatory signaling pathways (e.g., NF-κB inhibition)
● Neuroprotection mechanisms
● Cancer cell migration and invasion pathways
● Novel peptide therapeutics development
CAS #: NA
Disclaimer:
All products are sold strictly for laboratory research purposes only. Not for human or veterinary use, consumption, therapeutic, or diagnostic application. By purchasing, you confirm you are a qualified professional and legally permitted to handle these materials in compliance with all applicable laws and regulations. Misuse, resale for unauthorized purposes, or unlawful application is strictly prohibited. Qualitide disclaims all liability for improper use, handling, or regulatory non-compliance.
| Weight | 1 oz |
|---|---|
| Size | 10 MG, 2 MG |
Related products
-
Anti-Aging Cosmetic
Tetrapeptide-30
Price range: $60.00 through $470.00 Add to cart This product has multiple variants. The options may be chosen on the product page -
Cosmetic Peptides
Dipeptide-2
Price range: $28.00 through $196.00 Add to cart This product has multiple variants. The options may be chosen on the product page -
Anti-Aging Cosmetic
Tripeptide-32 (Chronolux®) for Radiant Skin
Price range: $99.00 through $729.00 Add to cart This product has multiple variants. The options may be chosen on the product page
