ApoE-mimetic Peptides
ApoE-Mimetic Peptides are small synthetic peptides that mimic the function of apolipoprotein E (apoE). They are designed to overcome the limitations of apoE, such as its low half-life and poor bioavailability. ApoE mimetic peptides have shown therapeutic potential in a variety of conditions, including Alzheimer's disease, traumatic brain injury, and cardiovascular disease.
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COG449/OP449: Overview and Information COG449 was originally developed by Cognosci, Inc., later by Oncotide Pharmaceuticals, and therefor name OP449. How It Works COG449/OP449 is a cell-penetrating peptide designed to interrupting intracellular protein-protein interaction associated with tumor growth. It inhibits the SET oncoprotein, which is...
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COG1410 is an apolipoprotein E-derived peptide. COG1410 exerts neuroprotective and anti-inflammatory effects in a murine model of traumatic brain injury (TBI) and cerebral stroke. COG1410 can be used for the research of neurological disease. Purity: >98% Molecular Weight: 1408.78Molecular Formula: C64H121N21O14CAS No. 878009-24-6Appearance: SolidColor: White to off-whiteSequence: Ac-AS-{Aib}-LRKL-{Aib}-KRLL-NH2Shipping: Room...
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$240.00 USD- from $120.00 USD
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COG112 is an apolipoprotein E (ApoE)-mimetic peptide by conjugating ApoE's receptor-binding domain (COG133) with a cell penetrating peptide (CPP) antennapedia (Antp). Introduction of CPP to COG133 significantly enhances the anti-inflammatory properties and neuroprotective activity of COG133. COG112 is particularly studied for its potential to...
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Biological Activity for COG133 COG 133 is an apolipoprotein (ApoE) peptide fragment that functions via the low-density lipoprotein receptor-related protein (LRP). Substantially reduces the symptoms of experimental autoimmune encephalomyelitis, a model of human multiple sclerosis, and suppresses inflammation, demyelination and infiltration of cells into...
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