What is Pentapeptide-18 (Leuphasyl®)?
Pentapeptide-18, commonly known as Leuphasyl®, is a synthetic neuropeptide designed to reduce facial muscle contractions and visibly smooth expression wrinkles. With a sequence of Tyr-D-Ala-Gly-Phe-Leu, it mimics the activity of natural enkephalins—endogenous peptides that modulate neuronal excitability.
Leuphasyl® offers a non-invasive, topical alternative to Botox®, delivering anti-aging effects without needles or downtime.
Pentapeptide-18 (Leuphasyl®) Benefits for Skin
- Expression Line Reduction: Relaxes facial muscles, helping smooth out dynamic wrinkles like crow’s feet and forehead lines.
- Muscle Relaxation: Inhibits acetylcholine release, reducing nerve signals that cause muscle contractions.
- Anti-Aging Use: Supports youthful skin texture by softening lines caused by repeated expressions.
- Quick Visible Results: Consistent use helps diminish wrinkle depth, improving skin smoothness and firmness.
- Safe, Gentle Mechanism: Acts via G protein-coupled receptors without toxic effects or invasive procedures.
How Leuphasyl® Works
- Mimics Enkephalins: Leuphasyl® binds to specific receptors (enkephalin receptors) on nerve cells, simulating natural muscle-calming signals.
- Modulates Calcium Channels: It triggers the release of G protein subunits that block calcium (Ca²⁺) influx, essential for acetylcholine release at neuromuscular junctions.
- Reduces Muscle Contraction: With lower neurotransmitter output, facial muscles relax; leading to a visible reduction in dynamic wrinkles.
Applications in Skincare
- Anti-aging serums and creams
- Eye-area wrinkle treatments
- Forehead and frown line correctors
- Leuphasyl vs Botox for Fine Lines: Ideal for users looking for Botox-like results without injections
Where to Buy Leuphasyl® Peptide?
Looking for where to buy Leuphasyl® peptide online? Our cosmetic-grade Pentapeptide-18 (Leuphasyl®) is purity-tested and ready for use in professional skincare formulations.
Technical Information
- INCI Name: Pentapeptide-18
- CAS Number: 64963-01-5
- Mechanism: Neuromodulator (calcium channel inhibitor)
- Functions: Wrinkle-reducing, skin-smoothing, expression line treatment
- Form: Water-soluble peptide for easy formulation
Why Choose Leuphasyl®?
Leuphasyl® is a trusted and scientifically validated anti-aging ingredient offering Botox-like results through a topical, non-invasive approach. Its unique peptide-based mechanism of neuromuscular relaxation makes it ideal for advanced wrinkle-smoothing formulations aimed at dynamic facial lines.
Disclaimer:
All products are sold strictly for laboratory research purposes only. Not for human or veterinary use, consumption, therapeutic, or diagnostic application. By purchasing, you confirm you are a qualified professional and legally permitted to handle these materials in compliance with all applicable laws and regulations. Misuse, resale for unauthorized purposes, or unlawful application is strictly prohibited. Qualitide disclaims all liability for improper use, handling, or regulatory non-compliance.





