Palmitoyl Hexapeptide-12 (Biopeptide El™)

What is Palmitoyl Hexapeptide-12?
Palmitoyl Hexapeptide-12, also known as Biopeptide El™, is a conjugate of palmitic acid and a peptide with the sequence Val-Gly-Val-Ala-Pro-Gly. This sequence is a fragment of elastin, known as the "spring fragment," which is highly repeated in the elastin protein. It plays a vital role in boosting the production of collagen, elastin, fibronectin, and glycosaminoglycans (GAGs), key components of the skin’s extracellular matrix (ECM).

How Palmitoyl Hexapeptide-12 Works

1. Enhanced Delivery with Palmitic Acid:
   The attachment of palmitic acid to the hexapeptide creates a more lipophilic structure, improving its skin penetration and bioactivity. This allows the peptide to reach deeper layers of the skin for effective results.

2. Elastin Fragment Function:
   The peptide sequence mimics elastin’s "spring fragment," stimulating fibroblasts to produce collagen, elastin, and GAGs, which contribute to skin’s firmness, elasticity, and hydration.

3. Chemotactic Properties:
   Palmitoyl Hexapeptide-12 has a chemotactic effect, attracting fibroblasts to sites of inflammation or damage, promoting healing and rejuvenation.

4. Restructuring Effect:
   Biopeptide El™ strengthens the skin structure, improving firmness, tone, and moisture levels.

5. Synergy with Ceramide NG (Dermaxyl™):
   Research shows that combining Palmitoyl Hexapeptide-12 with Ceramide NG enhances anti-aging effects, improves skin barrier function, and increases hydration.

Key Benefits

• Boosts Collagen and Elastin: Stimulates fibroblasts to increase collagen, elastin, and ECM components for firmer, more elastic skin.
• Reduces Signs of Aging: Improves skin tone, texture, and reduces fine lines and wrinkles.
• Enhances Hydration: Supports skin moisturization for a plump and smooth appearance.
• Restructures and Firms Skin: Strengthens the skin’s architecture, especially on the neck and face.
• Promotes Skin Healing: Attracts fibroblasts to repair and rejuvenate damaged or inflamed areas.
• Synergistic with Ceramides: Works with Ceramide NG (as in Dermaxyl™) to amplify anti-aging and hydrating effects.

Applications

Palmitoyl Hexapeptide-12 is ideal for use in:

• Anti-aging creams and serums
• Skin firming and toning products
• Hydrating and moisturizing formulations
• Neck and décolleté treatments
• Advanced skin repair products

Functions

• Firming
• Anti-aging
• Skin Conditioning

Technical Information

• CAS Number(s): 171263-26-6
• Molecular Formula: C₃₈H₆₈N₆O₈
• Molecular Weight: 737.0 g/mol
• CAS Number: 171263-26-6
• Sequence: Pal-Val-Gly-Val-Ala-Pro-Gly (pal-VGVAPG)
• FDA UNII: HO4ZT5S86C

Why Choose Palmitoyl Hexapeptide-12 (Biopeptide El™)?

Palmitoyl Hexapeptide-12 is a scientifically backed, multi-functional peptide that offers powerful anti-aging, firming, and hydrating benefits. Its ability to stimulate collagen, elastin, and ECM production makes it a vital ingredient in high-performance skincare products targeting aging and sagging skin.